Course Outline
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- Hemoglobinopathies
- Hemoglobinopathies
- Examples of Structural Abnormalities
- Hemoglobinopathies can be caused by all of the following structural defects except:
- Sickle Cell Disorders
- Sickle Cell Disorders
- To produce hemoglobin S, glutamic acid that is normally present in the sixth position on the beta globin chain is substituted with which of the follow...
- Sickle Cell Disorder Frequencies: Hb SS and Hb SA
- Sickle Cell Disorder Frequency: Hb S with Other Hemoglobins
- Sickle Cell Disorder Frequency: Hb S / Thalassemia
- Sickle Cell Disorder Frequency: Hb S with Hereditary Persistence of Fetal Hemoglobin
- The Sickling Process
- Sickling Process Overview
- The Sickling Process
- The Sickling Process, continued
- Normal Blood Flow
- Blood Flow During Sickling
- Vascular Occlusion
- Cellular Dehydration
- True or False: The first time a cell containing Hb SS is deoxygenated, it forms an irreversibly sickled cell.
- Clinical Manifestations of Sickle Cell Disease
- Clinical Manifestations of Sickle Cell Disease (SCD)
- Vaso-occlusive Crisis
- Vaso-occlusive Crisis, continued
- Sequestration Crisis
- Hemolytic Crisis
- Aplastic Crisis
- In sickle cell anemia, an increased amount of which of the following surface antigens on reticulocytes may allow platelets to form a bridge between th...
- Which of the following will not increase during hemolysis?
- Complications
- Risk Factors
- Which of the following options could cause a sickling event?
- Treatment of Sickle Cell Disease
- Laboratory Findings in Sickle Cell Disorders
- Solubility Test
- Hemoglobin Electrophoresis
- HPLC and Other Methods
- High Performance Liquid Chromatography, Capillary Electrophoresis, and Isoelectric Focusing
- Genetic Testing
- Other Methods of Detecting Hb S
- A technique that utilizes high voltage and separates hemoglobin on a polyacrylamide gel is called:
- Red Blood Cell Morphologies in Sickle Cell Disorders
- Case Studies
- Sickle Cell Trait
- Sickle Cell Disease
- Hemoglobin SC Disease
- CBC and RBC Morphology
- Hemoglobin Electrophoresis
- Hb S/Beta thalassemia
- Hb S with Hereditary Persistence of Fetal Hemoglobin (HPFH)
- References
Additional Information
Level of instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory technicians, laboratory supervisors, and laboratory managers. This course is also appropriate for MLS and MLT students and pathology residents.
Author Information: Lillian Mundt, EdD, MLS(ASCP)SH is currently employed by AMITA Adventist Hinsdale Hospital in the Molecular Pathology Department. She received her BA degree in Medical Technology from Aurora College, Aurora, Illinois. Her graduate work was completed at Governor's State University, University Park, Illinois, from which she received her Master of Health Science in Allied Health Professions Education; her doctorate in Educational Leadership was earned from the University of Phoenix. Her work experience includes a position as a medical technologist in hematology for over 30 years at Hinsdale Hospital, Department of Pathology. Lillian also taught at Hinsdale Hospital School of Medical Technology and the Rosalind Franklin University of Medicine and Science Department of Clinical Laboratory Sciences.
Reviewer Information:
David J. Moffa, PhD, BCLD has over 30 years of experience in the healthcare industry as an executive manager, clinical laboratory director, and medical laboratory scientist. He is currently a technical consultant for Kentmere Healthcare, Wilmington, DE, and until his retirement, was the Regional Director for LabCorp, Inc. He holds a PhD in medical biochemistry from the School of Medicine, West Virginia University.
Joshua J. Cannon, MS, MLS(ASCP)CMSHCM received his Bachelor
of Science and Master of Science in Medical Laboratory Science from Thomas
Jefferson University in Philadelphia, PA. He holds Medical Laboratory Scientist
and Specialist in Hematology certifications through the ASCP Board of
Certification. He was a professor at Thomas Jefferson University for seven
years before transitioning into his current role as Education Developer at
MediaLab. His areas of expertise and professional passions include clinical
hematology and interprofessional education.
