Overview of Histone Modifications - LabCE.com, Laboratory Continuing Education

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The page below is a sample from the LabCE course Epigenetics: Diagnostic Methods in the Clinical Laboratory. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Overview of Histone Modifications

1. Methylation of DNA and histones causes nucleosomes to pack tightly together. For instance, transcription factors cannot bind the DNA, and genes are not expressed.

2. Histone acetylation results in loose packing of nucleosomes. The transcription factors can then bind to the DNA and genes are expressed.

5. "Eukaryotic Epigenetic Gene Regulation." Lumen Learning. Available at: https://courses.lumenlearning.com/wm-biology1/chapter/reading-eukaryotic-epigenetic-gene-regulation.