Corynebacterium amycolatum (formerly known as CDC Groups F-2 and I-2) is a non-lipophilic species and is unusual in that it does not contain any mycolic acids in its cell wall but 16S RNA sequencing has shown that it does belong to the genus Corynebacterium.
This species has been implicated in septicemia, endocarditis, meningitis, otitis media, urinary tract infections, wound infections, and septic arthritis. Many of the patients with Corynebacterium amycolatum as a causative agent of infection have been immunocompromised or had surgical intervention.
C. amycolatum typically grows as a dry, waxy, grayish-white colony with irregular edges. CAMP is negative and isolates will ferment glucose, fructose, and mannose.