Clopidogrel Dosing

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The page below is a sample from the LabCE course Antiplatelet Medication Response Testing: Aspirin and Clopidogrel. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Clopidogrel Dosing

Clopidogrel is used in the treatment of various cardiovascular conditions. These conditions have their own recommended dosages as shown below. Platelet inhibition can often be demonstrated two hours after a single dose of oral clopidogrel. However, the absorption and distribution of the drug may be too slow for some conditions. Therefore, a loading-dose of 300 mg may need to be administered. The table below lists dosage recommendations for various conditions. In all cases, clopidogrel is given orally.

Condition
Recommended Dosage
Recent myocardial infarction (MI), recent stroke, or peripheral arterial disease (PAD)
75 mg once daily
Coronary artery disease (CAD)
75 mg once daily
Secondary prevention of cardioembolic stroke (patient not a candidate for oral anticoagulation, eg, warfarin)
75 mg once daily
Acute coronary syndrome (ACS)
300 mg initially followed by 75 mg daily