The Matrix Interferents

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The page below is a sample from the LabCE course Minimizing Pre-Analytical Variability During Venipuncture, Urine Sample Collection, and Sample Processing. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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The Matrix Interferents

Components may exist within the sample matrix that could affect the accuracy of the measured analyte.

Matrix Effect
Interfering Substance
Hemolysis (A)
Hemoglobin
Lipemia (B)
Triglycerides and chylomicrons
Icterus (C)
Bilirubin
Viscosity
Protein and immunoglobulins

For many analytes, studies have been performed by the manufacturer of the assay or analytical reagents to test the effects of these matrix interferents at various concentrations of the interfering substances. For laboratory-developed tests, or tests for which such interference studies are not available, the laboratory should perform interference testing.