Candida glabrata are smaller, ranging from 2 - 4 µm in diameter, and cannot produce hyphae or pseudohyphae.
C. glabrata can be morphologically difficult to distinguish from Histoplasma capsulatum. The presence of a predominately neutrophilic inflammatory response to C. glabrata is helpful in distinguishing infection with this organism from H. capsulatum; a hallmark of infections with the latter is a granulomatous response, comprised largely of macrophages. Candida spp. other than C. glabrata cannot be distinguished from one another morphologically.
11. CDC/Haley. Image #3769. This photomicrograph revealed some of the ultrastructural morphology exhibited by the fungal organism, Candida glabrata, formerly known as Torulopsis glabrata. C. glabrata is a common yeast species found on the body surface and is implicated in superficial and systemic infections, especially in immunocompromised patients. PHIL public domain. Created 1969. Accessed January 13, 2023. https://phil.cdc.gov/Details.aspx?pid=3769
