Case Study: Poikilocytosis and Basophilic Stippling

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The page below is a sample from the LabCE course Red Cell Disorders: Peripheral Blood Clues to Nonneoplastic Conditions. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Case Study: Poikilocytosis and Basophilic Stippling

In the images to the right, the poikilocytosis present includes teardrop cells, schistocytes, and target cells. In addition, macrocytes are present, two of which (one in each field) have coarse basophilic stippling. The stippling may represent abnormal hemoglobin synthesis. These stippled erythrocytes remain in circulation in the absence of pitting by a spleen.