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Table 5: Rouleaux and Agglutination
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Red Cell Disorders: Peripheral Blood Clues to Nonneoplastic Conditions
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Table 5: Rouleaux and Agglutination
Cell Type
Image
Cellular Description
Associated Diseases and Conditions
Rouleaux
Red blood cells (RBCs) appear as "stacked coins"
Cells overlap each other
Stacked-coin morphology is noted throughout the peripheral blood smear
Conditions associated with increased concentrations of globulins and/or fibrinogen
Hyperparaproteinemias
Waldenström macroglobulinemia
Multiple myeloma
Chronic inflammatory disorders
Agglutination
Clusters of RBCs due to antigen-antibody reactions in vivo
Cannot distinguish the outlines of individual RBCs
Cold agglutinins (most often IgM antibodies)
Paroxysmal cold hemoglobinuria
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