Table 5: Rouleaux and Agglutination - LabCE.com, Laboratory Continuing Education

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Table 5: Rouleaux and Agglutination

Cell Type	Image	Cellular Description	Associated Diseases and Conditions
Rouleaux		Red blood cells (RBCs) appear as "stacked coins" Cells overlap each other Stacked-coin morphology is noted throughout the peripheral blood smear	Conditions associated with increased concentrations of globulins and/or fibrinogen Hyperparaproteinemias Waldenström macroglobulinemia Multiple myeloma Chronic inflammatory disorders
Agglutination		Clusters of RBCs due to antigen-antibody reactions in vivo Cannot distinguish the outlines of individual RBCs	Cold agglutinins (most often IgM antibodies) Paroxysmal cold hemoglobinuria