The Oncofetal Antigens

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The page below is a sample from the LabCE course Tumor Markers. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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The Oncofetal Antigens

During fetal development, the developing embryonic tissues produce specific proteins that support the organism's function, growth, and development. These proteins are later replaced by proteins that play specific structural or transport roles throughout the organism's or individual's adult life.
Occasionally, tumor cells develop that begin producing these proteins associated with fetal development, called oncofetal antigens. The most widely studied oncofetal antigens are:
  • Alpha-fetoprotein (AFP)
  • Carcinoembryonic antigen (CEA)