Steady State

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The page below is a sample from the LabCE course Pharmacology for the Clinical Chemist: Therapeutic Drug Monitoring and Pharmacogenomics. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Steady State

Most drugs are not given as a single dose but are part of a multidose regimen. It is the physician's responsibility to prescribe a drug such that the concentration of that drug reaches a safe and effective level as quickly as possible without inducing toxicity. The goal for the prescribing clinician, if multiple doses of a drug will be given, is for both the peak and the trough drug levels to be consistently within the therapeutic range.
If a drug is given at intervals that are the same as its half-life, it will take about 5 half-lives to reach steady state.