Group 2
People who are at high risk for developing TB disease after infection with Mycobacterium tuberculosis. These individuals are more likely to progress from LTBI to active TB disease:
- Recent tuberculin skin test converters
- HIV-infected
- Young children under the age of 5
- A history of prior, untreated lesions on chest x-ray
- Injection drug users
- Those receiving specialized treatment for rheumatoid arthritis or Crohn's disease
- Immunosuppressed or immunocompromised patients (e.g., cancer patients, diabetics, transplant patients, patients in renal failure)
- Populations defined locally as having increased incidence of TB disease (including medically underserved and low-income populations)
