First, you need to exclude underlying alloantibodies. Workups may vary amongst facilities but may include performing the following:
- Direct Antiglobulin Test (DAT)
- Elution
- Patient phenotyping (if patient has not been transfused in past 3 months)
- Adsorptions (either allo or auto based on patient's transfusion history)
- Transfusing antigen negative blood (depending on your facility's recommendations)
