Acute Monoblastic Leukemia (AMoL)

How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 176 CE courses, most popular
$109Add to cart
Pick Your Courses
Up to 8 CE hours
$55Add to cart
Individual course$25Add to cart
Need multiple seats for your university or lab? Get a quote
The page below is a sample from the LabCE course Body Fluid Differential Tutorial. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Body Fluid Differential Tutorial (online CE course)
Acute Monoblastic Leukemia (AMoL)

This cytospin is from a case of acute monoblastic leukemia (AMoL) in a patient with central nervous system involvement.
These blasts are much larger than the blasts in the previous cases.
The morphology in this smear is consistent with the classification of M5a. M5a stands for "monoblastic without maturation," which is appropriate in this case since there are no promonocytes or monocytes present.
When a patient has an established diagnosis of M5b, abnormal promonocytes would be evident.
It is important to note that each individual patient's morphology will vary depending on the morphology of their original leukemia. If the patient relapses, the morphologies observed in both the cerebrospinal fluid and peripheral smears may become more extreme, since therapy selects for the most abnormal and resistant clones.