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The page below is a sample from the LabCE course Body Fluid Differential Tutorial. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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This slide is a cytospin preparation of a cerebrospinal fluid (CSF). The arrows point to slightly activated normal lymphocytes. The cytoplasm is pastel blue and non-granular, identical to what one would expect to see in slightly viral peripheral lymphocytes.

Note the nuclear chromatin texture and staining. The chromatin in these lymphocytes is a bit looser than the chromatin of a normal lymphocyte on a peripheral blood smear, but it has the same clumped appearance that is characteristic of normal lymphocytes.