Neuroblastoma Tumor Clump vs. Mesothelial Cells in Pleural Fluid

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The page below is a sample from the LabCE course Body Fluid Differential Tutorial. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Neuroblastoma Tumor Clump vs. Mesothelial Cells in Pleural Fluid

This image shows a neuroblastoma tumor clump (blue arrow) in the same field as several mesothelial cells (red arrows).
While the individual cells are the same overall size, the tumor cells have larger nuclei and a smaller amount of cytoplasm than the mesothelial cells. The chromatin is finer in the tumor cell nuclei. Also note the differences in the mesothelial cell chromatin pattern, which is much more coarse in texture with darker nucleoli present. The mesothelial cells have a distinct demarcation between adjacent cells, while this line of demarcation is not as apparent in the sheet of tumor cells.