Plasminogen Activator Inhibitor-1 (PAI-1)

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The page below is a sample from the LabCE course Metabolic Syndrome. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Plasminogen Activator Inhibitor-1 (PAI-1)

PAI-1 is a cytokine responsible for much of the prothrombotic state associated with metabolic syndrome. PAI-1 regulates the formation of thrombi by promoting formation of thrombin, platelet aggregation, and fibrin. PAI-1 inhibits fibrinolysis by blocking the activity of tissue-type plasminogen activator. PAI-1 is synthesized and released from the liver and adipocytes.

PAI-1 is increased in obesity, is associated with insulin resistance, and is an early inflammatory predictor of type 2 diabetes.