Comparison of Digene and Cervista HPV DNA Tests

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The page below is a sample from the LabCE course Human Papillomavirus (HPV) and Molecular Testing for Cervical Cancer. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Comparison of Digene and Cervista HPV DNA Tests

The table below compares the Digene and the two Cervista HPV Tests. All three methods use signal amplification.


Digene High Risk HPV HC2 DNACervista HPV HR ScreenCervista HPV 16/18
Probes RNA cocktail of RNA strands
    Complementary to HPV-assay types
      • Cocktail of nucleotide probes; complementary to assay HPV type's target region
      • Cocktail of nucleotides; complementary to one-half of target regions
      • Cocktail of nucleotide probes; complementary to type 16 and type 18 target region
      • Cocktail of nucleotides; complementary to one-half of type 16 and type 18 target region
      Hybridization ResultCreation of DNA:RNA hybrids Creation of 5' flaps Creation of 5' flaps
      Signal DetectedChemiluminescenceFluorescence Fluorescence
      Amplification Result3000 Fold 1-10 Million Fold 1-10 Million Fold
      Test ResultPositive or negative for the presence of the assay's HR-HPV typesPositive or negative for presence of the assay's HR-HPV typesPositive or negative for HPV 16;
      positive or negative for HPV 18