Comparison of Digene and Cervista HPV DNA Tests

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The page below is a sample from the LabCE course Human Papillomavirus (HPV) and Molecular Testing for Cervical Cancer. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Comparison of Digene and Cervista HPV DNA Tests

Table 2 compares the Digene and the two Cervista HPV Tests. All three methods use signal amplification.
Table 2. Comparison of Digene and Cervista HPV DNA Tests.

Digene High-Risk HPV HC2 DNACervista HPV HR ScreenCervista HPV 16/18
Probes
  • RNA cocktail of RNA strands
  • Complementary to HPV-assay types
  • Cocktail of nucleotide probes; complementary to assay HPV type's target region
  • Cocktail of nucleotides; complementary to one-half of target regions
  • Cocktail of nucleotide probes; complementary to type 16 and type 18 target region
  • Cocktail of nucleotides; complementary to one-half of type 16 and type 18 target region
Hybridization ResultCreation of DNA:RNA hybrids Creation of 5' flaps Creation of 5' flaps
Signal DetectedChemiluminescenceFluorescence Fluorescence
Amplification Result3000 Fold 1-10 Million Fold 1-10 Million Fold
Test ResultPositive or negative for the presence of the assay's HR-HPV typesPositive or negative for presence of the assay's HR-HPV typesPositive or negative for HPV 16;
positive or negative for HPV 18