Summary of Cytoplasmic Variations
| Name | Image | Description |
| Döhle Bodies | 
| Small, light blue-gray, irregular-staining patches of cytoplasm are seen near the edge of the cell. Associated with: - infections
- burns
- leukemia
- chemotherapy
- inflammatory states
|
| Toxic Granules |  | Large granules in the cytoplasm of segmented and band neutrophils in the peripheral blood. It can be dark, purplish blue, or almost red. Associated with: - infections
- Rheumatoid Arthritis (denatured proteins)
- autophagocytosis
|
| Vacuoles | 
| They appear as clear, unstained circular areas in the cytoplasm. Associated with: - bacterial infections
- septicemia
- aging cells
|
| Auer Rods | 
| Red-staining, needle-like bodies can be seen in the cytoplasm of myeloblasts and promyelocytes. Associated with: - Myeloproliferative neoplasms such as CML
- Acute myeloblastic leukemias such as AML and APL
|
| Chédiak-Higashi | 
| Cellular abnormality involving the fusion of cytoplasmic granules. These large abnormal granules can be seen in the cytoplasm of neutrophils, eosinophils, basophils, monocytes, and lymphocytes. Associated with: - Chédiak-Higashi syndrome (anomaly)
|
| May-Hegglin |  | Pale blue inclusions in neutrophils are sometimes referred to as Döhle-like bodies accompanied by giant platelets. Associated with: |
| Alder-Reilly | 
| Larger than normal purple-staining inclusions are seen in all mature white blood cells. Associated with: |
