Additional examples of hypochromic cells are seen on this slide. Notice the thin rim of hemoglobin and the large area of central pallor present in most of these cells. Hypochromic cells are unusually thin or in which the hemoglobin concentration is decreased. Decreased hemoglobin concentration can be caused by reduced amounts of iron available for hemoglobin production. The MCHC for this patient was significantly decreased (26 g/dL of RBCs), indicating a severe degree of hypochromia. When hypochromia is less severe, not all cells will be affected; thus, some cells may appear almost normal, whereas others are hypochromic.
