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The page below is a sample from the LabCE course Red Blood Cell (RBC) Morphology. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Spherocytes are red cells that have a decreased surface-to-volume ratio. As a result, this type of cell is denser than a normal red cell and on a Wright-stained smear, in the proper viewing area, they appear to be round, darkly-stained cells without central pallor. Two spherocytes are indicated by the arrows on this peripheral blood smear image.