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The page below is a sample from the LabCE course Red Blood Cell (RBC) Morphology. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Another Example of Macrocytosis

This peripheral blood smear is from a patient with vitamin B-12 deficiency anemia (pernicious anemia), which results from an inability to absorb the vitamin B-12 needed for DNA synthesis. Since many cells are destroyed in the bone marrow, decreased numbers of red cells are present in the circulating blood, resulting in anemia. The red cells that are present are generally macrocytes.