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The page below is a sample from the LabCE course Chronic Myeloid Leukemia (CML). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Chronic Myeloid Leukemia (CML) (online CE course)

  • CML cases have the characteristic t(9;22) translocation called the Philadelphia chromosome which can be detected by karyotyping.
  • CML cases have the gene mutation BCR-ABL1 that can be detected by PCR (polymerase chain reaction) or NGS (next generation sequencing) which is a DNA based technology thats test for gene mutation.
  • The Philadelphia chromosome (BCR-ABL) can also be detected by fluorescent in situ hybridization (FISH) which is a dual color (orange & green) staining that can be examined and detected with a fluorescent microscope (fusion product appears yellow). Image A and B show CML's bcr/abl fusion; Image N is of normal unaffected cells. Images from