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The page below is a sample from the LabCE course
Chronic Myeloid Leukemia (CML)
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Learn more about Chronic Myeloid Leukemia (CML) (online CE course)
Cytogenetics
Cytogenetics:
CML cases have the characteristic t(9;22) translocation called the Philadelphia chromosome which can be detected by karyotyping.
CML cases have the gene mutation BCR-ABL1 that can be detected by PCR (polymerase chain reaction) or NGS (next-generation sequencing), which is a DNA-based technology that tests for gene mutation.
The Philadelphia chromosome (BCR-ABL) can also be detected by fluorescent in situ hybridization (FISH), which is a dual color (orange & green) staining that can be examined and detected with a fluorescent microscope (fusion product appears yellow). The image to the right shows a normal cell pattern compared to a bcr/abl fusion pattern seen in CML.
2. Raca, Gordana. “BCR-Abl Fish.”
ImageBank
, https://imagebank.hematology.org/image/60151/bcrabl-fish.
Normal cell pattern versus positive BCR/ABL1 fusion pattern in FISH (2).
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