RhIG is indicated in these circumstances:
- Pregnancy termination through delivery or abortion
- Antepartum fetomaternal hemorrhage (FMH), suspected or proven as a result of placenta previa, amniocentesis, chorionic villus sampling, cordocentesis, other obstetrical manipulative procedures (e.g., external version or abdominal trauma such as may occur in a car accident or fall)
- Vaginal bleeding during pregnancy
- Loss, or threatened loss, of fetus at any gestational stage
- Ectopic pregnancy
For non-routine indications, depending on the level of medical care the pregnant patient receives or the awareness level of the risks involved, there is increased potential for RhIG to be administered inappropriately or not at all.