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The page below is a sample from the LabCE course Chronic Kidney Disease. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Chronic Kidney Disease - Epidemiology (CKD-EPI) Equation

In 2009, the Chronic Kidney Disease - Epidemiology equation was first reported in the Annals of Internal Medicine (Levey, 2009). This equation added additional factors, using a two-spline model in its estimates of GFR to improve accuracy. It is the primary equation recommended for use in estimating GFR by international experts (KDIGO, 2013).
Key characteristics include:
  • More accurate at GFR > 60 mL/min/m2
  • Validated in age groups that exceeded that of the MDRD
  • Continues to exhibit inaccuracies in very young patients
eGFR = 141 x min(SCr/κ, 1)α x max(SCr/κ, 1)-1.209 x 0.993Age x 1.018 [if female] x 1.159 [if African descent]
κ = 0.7 (female) or 0.9 (male)
α = -0.329 (female) or -0.411 (male)