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The page below is a sample from the LabCE course Myeloproliferative Neoplasms. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Diagnosis of Essential Thrombocythemia (ET): Bone Marrow Findings

ET is usually characterized by a hypercellular bone marrow, including increased numbers of megakaryocytes. Other features include: giant megakaryocytes, clusters of megakaryocytes, or other dysplastic megakaryocytic changes. Bone marrow reticulin is usually increased, although collagen fibrosis is rare. The image shown below is a bone marrow biopsy showing megakaryocytic hyperplasia and clustering. These features are consistent with ET. The arrows in the image point to a cluster of megakaryocytes and an abnormal, multi-lobulated megakaryocyte.
Secondary or reactive thrombocytosis and polycythemia vera and other disorders can have similar features. Therefore, other criteria must be considered along with bone marrow findings when making a diagnosis of ET.

BM biopsy showing megakaryocytic hyperplasia and clustering consistent with essential thrombocythemia. Used with permission from: S G Holtan, J D Hoyer and F K Buadi.