Essential Thrombocythemia (ET)

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The page below is a sample from the LabCE course Myeloproliferative Neoplasms. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Essential Thrombocythemia (ET)

Essential thrombocythemia (ET) is a rare myeloproliferative neoplasm involving abnormalities in megakaryocytes, allowing them to overproliferate in the bone marrow. This disorder presents with markedly elevated platelet counts, typically greater than 600 x 109/L but very often greater than 1000 x 109/L, although these platelets are often dysfunctional. A markedly increased platelet count in a patient with ET is shown in the image provided.
Even though the megakaryocyte lineage is always affected, leukocyte and erythrocyte lineages can also show increases.
Increased incidence of ET has been reported in age groups from 20-30 years old and 50-60 years old. Women are more likely than men to develop the condition.
Essential thrombocythemia (ET) may also be referred to as essential thrombocytosis.

Essential thrombocythemia.