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Cockcroft-Gault Equation

In 1976, the Cockcroft-Gault equation for creatinine clearance (CCr) was developed, simplifying the estimation of glomerular filtration rate (GFR) based on the level of serum creatinine (SCr)alone (Cockcroft, 1976).
CCr (mL/min) = (140 - Age) x Weight / (72 x [SCr])
SCr: in mg/mL; Age: in Years; Weight: in kilograms (kg)
This equation is no longer recommended for routine use as:
  • It is a calculation of CCr, not GFR - the same overestimating limitations apply (Clarke, 2016)
  • It was not established using standardized creatinine assays, with subsequent loss of accuracy (Coresh, 2006)
More information: National Kidney Foundation