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The page below is a sample from the LabCE course Chronic Kidney Disease. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Cystatin C

Cystatin C (CysC) is a cysteine protease present in lysosomes of nucleated cells. It is produced at a constant rate and is freely filtered by the glomerulus. It is not secreted by the kidney and exhibits a similar relationship to GFR as creatinine. Diet and muscle mass have less effect on its concentration, but other factors such as age, sex, medications, and disease may influence its concentration (Clarke, 2016).
CysC is not measured in the urine as it is fully resorbed by the renal tubules. However, it is measured in plasma using standardized immunoassays and is useful for determining the eGFR.
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