Post-transplant infection is a potentially life-threatening condition that requires supportive care and preventive treatment. Due to immunosuppression and neutropenia, transplant patients are susceptible to various bacterial, fungal, and viral infections. Prophylactic antibiotic therapy, antifungal agents, and vaccinations are used to reduce the risk of infection. Cytomegalovirus (CMV) negative donors are preferred for patients who require blood components. Leukocyte-reduced blood products also will lower the risk of transmission of CMV to an immunosuppressed patient. Other necessary preventive measures include skin care and oral hygiene.