Coagulation Disorders - Acquired

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The page below is a sample from the LabCE course Fundamentals of Hemostasis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Coagulation Disorders - Acquired

A lack of Vitamin K can cause a loss of functionality in Vitamin K-dependent coagulation factors, specifically, factors II, VII, IX and X. Most often associated with a diet lacking in Vitamin K, it may also present in situations of broad spectrum antibiotic use, where normal flora in the gut have been eliminated.

As one might expect, treatment involves a diet rich in Vitamin K containing foods, and judicious use of broad spectrum antibiotics.
Note: The Vitamin-K dependent coagulation factors are also known as the Prothrombin group.