Coagulation Disorders - Inherited

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The page below is a sample from the LabCE course Fundamentals of Hemostasis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Coagulation Disorders - Inherited

Inherited disorders are those which are considered to be inborn, and have some familial linkage.

Hemophilia A is a deficiency of coagulation factor VIII. It is important to note that Hemophilia A can also be acquired, versus inherited, in cases where patients produce auto-antibodies against factor VIII. Following are other key points regarding hemophilia A:
  • It is the most commonly encountered hereditary coagulation disorder.
  • Found more commonly in males, its pattern of inheritance is sex-linked recessive.
  • This disorder presents clinically with hemorrhagic events ranging in severity from mild to severe. Patients often present with spontaneous bleeding into their joints, a classic symptom of this affliction.
The treatment of Hemophilia A often involves the administration of commercial factor VIII products.