The fibrinogen assay performed in the clinical laboratory is a quantitative measure of factor I. This assay determines whether enough fibrinogen is present to allow for normal clotting. It is performed in cases of an unexpected, prolonged bleeding event or abnormal PT and/or APTT. It is also used to diagnose disseminated intravascular coagulation (DIC).
A standard reference range is typically around 200–400 mg/dL.
- That range is significant because fibrinogen levels <100 mg/dL are often associated with free bleeding or impaired hemostatic function.
