Secondary Hemostasis – The Intrinsic Pathway

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The page below is a sample from the LabCE course Fundamentals of Hemostasis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Secondary Hemostasis – The Intrinsic Pathway

Next, activated factor XI (XIa) catalyzes the conversion of factor IX into IXa, in the presence of ionized Calcium. Then activated factor IX (IXa), along with ionized calcium, platelet factor, and factor VIII, activates factor X, which goes on to activate the next factor, prothrombin into thrombin in the common pathway.
The activation of factor X signals the beginning of the common pathway.
The activated partial thromboplastin time (APTT) is used to monitor the intrinsic pathway and the effectiveness of heparin therapy.