Secondary Hemostasis – The Extrinsic Pathway

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The page below is a sample from the LabCE course Fundamentals of Hemostasis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Secondary Hemostasis – The Extrinsic Pathway

Functional control of the extrinsic pathway is mediated by Tissue Factor Pathway Inhibitor (TFPI) which binds to and inhibits factor X.

Remember, for hemostatic processes to continue, factor VIIa must be able to promote the chemical conversion of factor X into factor Xa. TFPI effectively blocks this action, thereby controlling the initiation of the common pathway.
The Prothrombin time (PT) is used to monitor the extrinsic pathway, and the activity of oral anticoagulants such as warfarin.