Chromosome 11 Delta-Beta Thalassemia Major

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Chromosome 11 Delta-Beta Thalassemia Major

Delta-beta thalassemia major, Delta-beta 0/ Delta-beta0, exists when both gene loci for beta and delta chains are completely deleted or inactive on both chromosomes.

In this state, only Hb F can be made (two alpha chains, two gamma chains).

(drawing modified from Harmening, 1999)