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The page below is a sample from the LabCE course The Urine Microscopic: Microscopic Analysis of Urine Sediment. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Hyaline Casts

Hyaline casts consist of only the uromodulin protein matrix. A few hyaline casts (0-2/low power field) are considered normal. They may be visible in the urine sediment if the individual has been exercising heavily, has a fever; or is undergoing diuretic therapy.

Pathologically, hyaline casts may be seen with congestive heart failure, and may be seen together with other types of casts in a variety of renal diseases.
Hyaline casts are generally translucent and homogeneous but may contain a few granules within the matrix. Hyaline casts have a refractive index similar to urine and are easily missed. Visualization of these casts is enhanced by using subdued light or by using phase-contrast microscopy.
Formation of hyaline casts between the juncture of the ascending loop of Henle and the distal convoluted tubule may result in a cylindroid (tail) appearance at one end.