For the diagnosis of lupus anticoagulants, the International Society on Thrombosis and Hemostasis has set a protocol of diagnostic criteria that should be met. This includes the following requirements:
- The patient sample must show abnormal phospholipid-dependent reactions in the coagulation lab.
- The patient sample must show inhibition of clotting after the mixing study test has been performed.
- The patient sample must be proven to have an inhibitor, not a factor deficiency.
- The patient must have a definitive phospholipid-dependent antibody, not a specific factor inhibitor.
