Analyzing the Mixing Study Results

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The page below is a sample from the LabCE course Detecting and Evaluating Coagulation Inhibitors and Factor Deficiencies. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Analyzing the Mixing Study Results

A "corrected" mixing study result is a PT or aPTT result within a normal range of the pooled standard plasma control or approximately 10% of the normal range. A PT or aPTT test significantly prolonged at baseline may not completely correct to within the average reference interval on a 1:1 mix.
"No correction" would mean that the patient sample/pooled standard plasma mixture had no significant decrease in clotting time for the PT or aPTT compared to the initial PT/aPTT results.