When to Perform a Mixing Study

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The page below is a sample from the LabCE course Detecting and Evaluating Coagulation Inhibitors and Factor Deficiencies. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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When to Perform a Mixing Study

A mixing study should be considered when a patient has a prolonged PT and/or aPTT along with:
  • no history of heparin or warfarin therapy
  • no history of liver disease
It is also essential to verify that a correctly collected sample (i.e., free from clots) with a proper blood-to-anticoagulant ratio has been obtained.