CML - Accelerated Phase (AP)

How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 148 CE courses, most popular
$95Add to cart
Pick Your Courses
Up to 8 CE hours
$50Add to cart
Individual course$20Add to cart
Need multiple seats for your university or lab? Get a quote
The page below is a sample from the LabCE course Chronic Myeloid Leukemia (CML). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Chronic Myeloid Leukemia (CML) (online CE course)
CML - Accelerated Phase (AP)

It is important to distinguish the accelerated phase of CML from the chronic phase. The accelerated phase of CML indicates disease progression with worsening clinical condition and may require additional treatment. When one or more of the following criteria are present, the accelerated phase is indicated.
  1. Persistent increase of the WBC count, in-spite of therapy
  2. Increased splenomegaly, unresponsive to therapy
  3. Persistent thrombocytosis unresponsive to therapy or thrombocytopenia
  4. Develop additional cytogenetic abnormalities in addition to the t(9;22) - Philadelphia Chromosome
  5. Increased basophil count in the peripheral blood (>20% of total WBC count)
  6. Increase in the blasts number (10-19 %) in the peripheral blood and/or bone marrow
  7. Bone marrow hypercellularity with possible myeloid dysplasia

Basophils & blasts
Numerous basophils