It is important to distinguish the accelerated phase of CML from the chronic phase. The accelerated phase of CML indicates disease progression with worsening clinical condition and may require additional treatment. When one or more of the following criteria are present, the accelerated phase is indicated.
- Persistent increase of the WBC count, in-spite of therapy
- Increased splenomegaly, unresponsive to therapy
- Persistent thrombocytosis unresponsive to therapy or thrombocytopenia
- Develop additional cytogenetic abnormalities in addition to the t(9;22) - Philadelphia Chromosome
- Increased basophil count in the peripheral blood (>20% of total WBC count)
- Increase in the blasts number (10-19 %) in the peripheral blood and/or bone marrow
- Bone marrow hypercellularity with possible myeloid dysplasia