Transcription

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The page below is a sample from the LabCE course Precision Medicine-Molecular Mechanisms of Cancer Development and Actionable Genes. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Transcription

Transcription is the process where the DNA code is used as a template to create a complementary RNA strand. The conversion from DNA to RNA is performed using an enzyme called RNA polymerase. The RNA polymerase reads the DNA strand and incorporates nucleotides complementary to the DNA sequence into the growing RNA strand. As with DNA replication, guanine will still only bind to cytosine. However, the RNA polymerase will incorporate Uracil instead of Thymine when it encounters an adenine in the DNA sequence. If the RNA strand encodes a protein it is messenger RNA (mRNA). Alternatively, the RNA could encode for transfer RNA (tRNA) or ribosomal RNA (rRNA) to assist with translation.
Image courtesy of Wikimedia

DNA transcription