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The page below is a sample from the LabCE course Erythrocyte Inclusions. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Siderotic Granules

To verify that red cell inclusions contain iron, it is necessary to use an iron stain, such as Prussian blue. The iron-containing granules are called siderotic granules. Pappenheimer bodies are siderotic granules that are visible on a Wright-stained smear. All Pappenheimer bodies are Prussian blue positive, but not all siderotic granules are visible on Wright-stained smears as Pappenheimer bodies.
A mature erythrocyte containing siderotic granules is referred to as a siderocyte, while an immature (nucleated) erythrocyte containing siderotic granules is known as a sideroblast.