Bone marrow biopsy and blood smear results vary greatly in the different stages of disease progression.
In the CML-Chronic phase (CP), the peripheral blood shows leukocytosis ranging from slightly above normal (greater than12.0 x 109/L) to extremely high (over 100.0 x 109 /L).
The peripheral blood smear shows a predominance of neutrophil proliferation in different stages of maturation, with the majority of neutrophilic cells in the mature neutrophil and myelocyte stages. The granulocytes are relatively normal morphologically with minimal dysplastic features and no toxic changes. There is an increase in the percentage of eosinophils and basophils. The platelet counts range from normal to greater than 1 million/µL. Blast cells account for less than 2% of the WBC count.
