Morphology of the Peripheral Blood Smear

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The page below is a sample from the LabCE course Chronic Myeloid Leukemia (CML). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Morphology of the Peripheral Blood Smear

Bone marrow biopsy and blood smear results vary greatly in the different stages of disease progression.
In CML-Chronic phase (CP), the peripheral blood shows leukocytosis ranging between slightly above normal (greater than12.0 x 109/L) to extremely high (over 100.0 x 109 /L).
The peripheral blood smear shows a predominance of neutrophil proliferation in different stages of maturation with the majority of neutrophilic cells in the mature neutrophil and myelocyte stages. The granulocytes are fairly normal morphologically with minimal dysplastic features and no toxic changes. There is an increase in the percentage of eosinophils and basophils. The platelet counts range from normal to greater than 1 million/µL. Blast cells account for less than 2% of the WBC count.

Peripheral smear showing leukocytosis