Examples of Antibodies to Low-Prevalence Antigens

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The page below is a sample from the LabCE course Antibody Detection and Identification. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Examples of Antibodies to Low-Prevalence Antigens

Antibodies to low-prevalence antigens will be difficult to test for since most screen and panel cells do not have these antigens on the testing cells. Further testing may be needed at a reference laboratory where a larger selection of antibody panels are available to locate cells positive for these antigens.

Suspect an antibody to a low-prevalence antigen if:
  • AHG crossmatch is incompatible and
  • Other causes have been ruled out (i.e., positive donor DAT, ABO incompatibility)
Examples of antibodies to low-prevalence antigens are anti-f, anti-V, anti-Cw, anti-Kpa, anti-Jsa, and anti-Lua (highlighted in blue).
Rh-HrKellDuffyKiddLewisMNSsLutheran
VialDonorDCcEefVCwKkKpaKpbJsaJsbFyaFybJkaJkbLeaLebMNSsLuaLubISAHGCC
IR1R1++00+000++0+0++++00++00+0+002+
IIR2R2+0++00000+0+0++0+++0++++0+002+
Rh-HrKellDuffyKiddLewisMNSsPLutheran
Donor Cell NumberDCcEeCwKkKpaKpbJsaJsbFyaFybJkaJkbLeaLebMNSsP1LuaLubISAHGCC
1++00+00+0+0++0+++0+++++0+002+
2++00++++0+0+++0+0+0++++0+002+
3+0++000+0+0+0+0+0++00++0+002+
4+0+0+00+0+0+00+00++++0+0+002+
50++0+00+0+0++++++00+0+00+002+
600+++0++0+0+0+++0+++++00+002+
700+0+00+0+0++00++0+00++0+002+
800+0+00+0+0+++0+0+++++00+002+
900+0+00+0+0++++00+0++0+0+002+
10+0+0+0++0+0+0+0+0+0++0+0+002+
AC002+