Examples of Antibodies to High-Prevalence Antigens

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The page below is a sample from the LabCE course Antibody Detection and Identification. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Examples of Antibodies to High-Prevalence Antigens

Suspect an antibody to a high-prevalence antigen if:
  • Reactions with all screen and panel cells are positive (similar strength and same phase).
  • Autocontrol is negative.
Antibodies to high-prevalence antigens include anti-k, anti-Kpb, anti-Jsb, and anti-Lub (highlighted in blue).
Rh-HrKellDuffyKiddLewisMNSsLutheran
VialDonorDCcEefVCwKkKpaKpbJsaJsbFyaFybJkaJkbLeaLebMNSsLuaLubISAHGCC
IR1R1++00+000++0+0++++00++00+0+02+NT
IIR2R2+0++00000+0+0++0+++0++++0+02+NT
Rh-HrKellDuffyKiddLewisMNSsPLutheran
Donor Cell NumberDCcEeCwKkKpaKpbJsaJsbFyaFybJkaJkbLeaLebMNSsP1LuaLubISAHGCC
1++00+00+0+0++0+++0+++++0+02+NT
2++00++++0+0+++0+0+0++++0+02+NT
3+0++000+0+0+0+0+0++00++0+02+NT
4+0+0+00+0+0+00+00++++0+0+02+NT
50++0+00+0+0++++++00+0+00+02+NT
600+++0++0+0+0+++0+++++00+02+NT
700+0+00+0+0++00++0+00++0+02+NT
800+0+00+0+0+++0+0+++++00+02+NT
900+0+00+0+0++++00+0++0+0+02+NT
10+0+0+0++0+0+0+0+0+0++0+0+02+NT
AC002+