Crossmatch practices for RhIG-derived passive anti-D vary significantly.
Inclusion here does not indicate endorsement or lack thereof for a particular policy, but merely documents that such policies exist. All policies assume the following scenario:
- An Rh negative female has received antenatal RhIG;
- She has a positive antibody screen consistent with passive anti-D;
- A mini-panel has been done to exclude other clinically significant antibodies and shows only anti-D;
- If performed to detect possible ABO incompatibility, the electronic crossmatch or immediate spin (IS) crossmatch is done with Rh negative RBC whose D typing is confirmed in-house.