Initial Antibody Exclusions - LabCE.com, Laboratory Continuing Education

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The page below is a sample from the LabCE course Rh-Negative Mother with Anti-D at Delivery: A Case Study. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Rh-Negative Mother with Anti-D at Delivery: A Case Study (online CE course)

Initial Antibody Exclusions

Using the screen cell antigram below, we can see that the antibodies corresponding to the light teal-highlighted antigens have been eliminated.

Screen cell #3 is from a donor who is likely homozygous for c, e, k, Fy^a, Jk^b, Le^b, M, S, and Lu^b. Therefore, it excludes the corresponding antibodies.

Cell

Rh-Hr

Kell

Duffy

Kidd

Lewis

Lutheran

MNSs

C^w

Kp^a

Js^a

Fy^a

Fy^b

Jk^a

Jk^b

Le^a

Le^b

Lu^a

Lu^b

Xg^a

37°

AHG

R₁R₁

R₂R₂

√

Auto

√

Following the Antibody Exclusion Protocol, anti-P₁ and anti-Le^a can be excluded by a single negative with an antigen-positive red cell. Anti-Le^a is not a cause of HDFN as Le^a is poorly developed on fetal RBCs and the antibodies are not considered significant when identified in maternal serum.

Therefore, possible (not excluded) significant antibodies include anti-D, C, E, K, Fy^b, Jk^a, N, and s.

Antibody Exclusion Protocol