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The page below is a sample from the LabCE course Laboratory Evaluation of the Lupus Anticoagulant found in Antiphospholipid Syndrome (APS). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Clinical and Laboratory Criteria for the diagnosis of APS

Clinical criteria:
  1. Vascular thrombosis: defined as one or more clinical episodes of arterial, venous, or small-vessel thrombosis in any tissue or organ confirmed by findings from imaging studies, Doppler studies, or histopathology.
  2. Pregnancy morbidity is defined as the following:
    • One or more late-term (>10 weeks gestation) spontaneous abortions
    • One or more premature births of a morphologically healthy neonate at or before 34 weeks gestation because of severe preeclampsia or eclampsia or severe placental insufficiency
    • Three or more unexplained, consecutive, spontaneous abortions before 10 weeks gestation
Laboratory criteria:
  1. Lupus anticoagulant (LA): presents on two occasions at least 12 weeks apart with prolongation of at least one phospholipid dependent coagulation test.
  2. Anti-cardiolipin antibodies (ACA): IgG/IgM ACA antibodies detected in medium to high titer on at least two occasions at least 12 weeks apart measured by ELISA testing.
  3. Anti-ß2 GP1: IgG/IgM anti-ß2 GP1 detected on at least two occasions at least 12 weeks apart measured by ELISA testing.