Fortunately, the great majority of collections are uneventful, but from time to time problems or the unexpected occur. This section will discuss a few examples of special situations that may take place during a collection and what the response of the collector should be. Obviously, not every special situation can be envisioned or discussed. It is strongly recommended that the collector be very familiar with the DOT publication, Urine Specimen Collection Guidelines (revised January, 2018), and the HHS publication, Urine Specimen Collection Handbook (effective October 1, 2017). These guidelines are available at: