Dysplastic Granulocytic Cell Line (Dysgranulopoiesis)

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The page below is a sample from the LabCE course Myelodysplastic Syndromes (MDS). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Dysplastic Granulocytic Cell Line (Dysgranulopoiesis)

Normal neutrophils have 3-5 lobes and demonstrate the presence of secondary neutrophilic (pink) granules (please refer to the image on the right).
Dysplastic neutrophils may show:
  • Abnormal neutrophil sizes
  • Nuclear hypo-segmentation or hyper-segmentation
  • Decreased cytoplasmic granules (hypo-granular)
  • Psedo-Chediak-Higashi granules (abnormal large azurophilic granules)
  • Auer rods
Examples of Dysplastic Granulocytic Cells:
Hypo-granular, hypo-segmented neutrophil
Hypogranular neturophils
Hypersegmented neutrophil

Normal Neutrophils